Does sleep restore brain function or does it consolidate memory? I argue that memory consolidation during sleep is an offshoot of restitution. Continual learning causes local synapse-specific neural fatigue, which then masks expression of that learning, especially on time-limited tests of procedural skills. Sleep serves to restore the fatigued synapses, revealing the consolidation-based enhancement observed as a “latent” overnight improvement in learning.

It is commonplace for a single physiological mechanism to seed multiple phenomena, and for multiple mechanisms to contribute to a single phenomenon. We propose that the flash-lag effect should not be considered a phenomenon with a single cause. Instead, its various aspects arise from the convergence of a number of different mechanisms proposed in the literature. We further give an example of how a neuron's generic spatio-temporal response profile can form a physiological basis not only of but also of many (...) of the other proposed flash-lag mechanisms, thus recapitulating a spectrum of flash-lag phenomena. Finally, in agreeing that such basic predictive mechanisms are present throughout the brain, we argue that motor prediction contributes more to biological fitness than visual prediction. (shrink)

This paper makes an attempt to examine the various facets of human values in the background of the widely shared popular beliefs about erosion of values. A random sample of elite opinions on the nature of decline of values brings out the difficulties involved in identifying values for social analysis. Values are an integral part of the religious, spiritual and governmental spheres of social behaviour within a culture. It is argued that the problem of erosion of values is shared across (...) cultures and has existed throughout the history of human society. It is suggested that material and spiritual values follow a dialectical process of coexistence and conflict. The current wave of concern over degeneration of values is explained in relation to the unprecedented complexity of today's global society and the socio-economic challenges posed by this complexity for the individual and the society at various levels. This discussion is followed by a brief review of the recent contributions of social sciences to the concept of values and their decline in modern society. Finally, some thoughts are expressed, from a sociologist's vantage point, regarding the multi-dimensional problem of values in the emerging global culture. (shrink)

We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. (...) The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank. (shrink)

Bidirectional deep brain stimulation (DBS) platforms have enabled a surge in hours of recordings in naturalistic environments, allowing further insight into neurological and psychiatric disease states. However, high amplitude, high frequency stimulation generates artifacts that contaminate neural signals and hinder our ability to interpret the data. This is especially true in psychiatric disorders, for which high amplitude stimulation is commonly applied to deep brain structures where the native neural activity is miniscule in comparison. Here, we characterized artifact sources in recordings (...) from a bidirectional DBS platform, the Medtronic Summit RC + S, with the goal of optimizing recording configurations to improve signal to noise ratio (SNR). Data were collected from three subjects in a clinical trial of DBS for obsessive-compulsive disorder. Stimulation was provided bilaterally to the ventral capsule/ventral striatum (VC/VS) using two independent implantable neurostimulators. We first manipulated DBS amplitude within safe limits (2–5.3 mA) to characterize the impact of stimulation artifacts on neural recordings. We found that high amplitude stimulation produces slew overflow, defined as exceeding the rate of change that the analog to digital converter can accurately measure. Overflow led to expanded spectral distortion of the stimulation artifact, with a six fold increase in the bandwidth of the 150.6 Hz stimulation artifact from 147–153 to 140–180 Hz. By increasing sense blank values during high amplitude stimulation, we reduced overflow by as much as 30% and improved artifact distortion, reducing the bandwidth from 140–180 Hz artifact to 147–153 Hz. We also identified artifacts that shifted in frequency through modulation of telemetry parameters. We found that telemetry ratio changes led to predictable shifts in the center-frequencies of the associated artifacts, allowing us to proactively shift the artifacts outside of our frequency range of interest. Overall, the artifact characterization methods and results described here enable increased data interpretability and unconstrained biomarker exploration using data collected from bidirectional DBS devices. (shrink)

Recent advances in wireless data transmission technology have the potential to revolutionize clinical neuroscience. Today sensing-capable electrical stimulators, known as “bidirectional devices”, are used to acquire chronic brain activity from humans in natural environments. However, with wireless transmission come potential failures in data transmission, and not all available devices correctly account for missing data or provide precise timing for when data losses occur. Our inability to precisely reconstruct time-domain neural signals makes it difficult to apply subsequent neural signal processing techniques (...) and analyses. Here, our goal was to accurately reconstruct time-domain neural signals impacted by data loss during wireless transmission. Towards this end, we developed a method termed Periodic Estimation of Lost Packets. PELP leverages the highly periodic nature of stimulation artifacts to precisely determine when data losses occur. Using simulated stimulation waveforms added to human EEG data, we show that PELP is robust to a range of stimulation waveforms and noise characteristics. Then, we applied PELP to local field potential recordings collected using an implantable, bidirectional DBS platform operating at various telemetry bandwidths. By effectively accounting for the timing of missing data, PELP enables the analysis of neural time series data collected via wireless transmission—a prerequisite for better understanding the brain-behavior relationships underlying neurological and psychiatric disorders. (shrink)

DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers can freely discuss current and emerging deep brain stimulation technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in (...) its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury. (shrink)

Introduction: Consultation methods differ between medical practitioners depending on the individual setting. However, the central tenet to the doctor–patient relationship is the issue of confidentiality. This prospective survey highlights patient attitudes towards consultation methods in the setting of an ophthalmic outpatient department. Method: Questionnaires were completed by 100 consecutive patients, who had been seen by an ophthalmologist in a single room, which had a joint doctor–patient consultation occurring simultaneously. Results: Each question of all 100 questionnaires was completed. 58% of patients (...) were not concerned about sharing a consultation room with another patient or doctor. However, this did not equate to the 49% of patients who were indifferent to discussing issues in the joint consultation room. The most common factor was the general issue of confidentiality. Discussion: Ensuring total patient confidentiality may be deemed more necessary for certain medical specialties than for others, as seen in the practice of separate medical records in genitourinary medicine, for instance. However, with regard to patient consultations, the same level of confidentiality should be afforded across all specialties, and such factors should be borne in mind when planning outpatient clinics. (shrink)

Lectures delivered in Sheth Shri Popatlal Hemchand Adhyatma vyakhyanamala, organized by B.J. Institute of Learning and Research with special references to Jaina doctrines and philosophy.

Розкрито сутність поняття «рейтинг». Доведено значущість рейтингової оцінки для суб’єктів фінансового ринку, зокрема для страхових компаній, потенційних страхувальників, інвесторів та кредиторів.

"Williams's masterful translation satisfies (at last!) a long-standing need. There are lots of good translations of Augustine's great work, but until now we have been forced to choose between those that strive to replicate in English something of the majesty and beauty of Augustine's Latin style and those that opt instead to convey the careful precision of his philosophical terminology and argumentation. Finally, Williams has succeeded in capturing both sides of Augustine's mind in a richly evocative, impeccably reliable, elegantly readable (...) presentation of one of the most impressive achievements in Western thought--Augustine's Confessions." --Scott MacDonald, Professor of Philosophy and Norma K. Regan Professor in Christian Studies, Cornell University. (shrink)

Examines how liberal society enables racism and other forms of discrimination.

This book offers a critical introduction to the work of American philosopher D. G. Leahy (1937-2014). Leahy's fundamental thinking can be characterized as an absolute creativity in which all creating is 'live' -- a happening occurring now that manifests a supersaturated polyontological actuality that is essentially created by the logic that characterizes it. Leahy leaves behind the categorial presuppositions of modern thought, eclipsing both Cartesian and Hegelian subjectivities and introducing instead an essentially new form of thinking founded in a nondual (...) logic of creation. The new thinking delineates the absolute unicity of existence as a creative interactivity beyond all traditional dichotomies (such as one vs. many, unity vs. plurality, identity vs. change): a fully "digitized" actuality that is nothing but newness, which inherently implies nothing but change. Through this new form of thinking, change itself is revealed to be the very essence of reality and mind. Any reader looking for a quantum leap beyond the thrall of modern and postmodern fixations is invited to hear and apprehend this new thinking that refuses to be conditioned by paradigms, categories, species, genera, walls, bridges, boundaries, or abstractions: an essentially free thinking that embodies creative novelty itself. (shrink)

We conduct an experiment to investigate the degree to which deviations from exponential discounting can be accounted for by the hypothesis of hyperbolic discounting. Subjects are asked to choose between an earlier or later payoff in a series of 40 choice questions. Each question consists of a pair of monetary amounts determined by compounding a given base amount at a constant rate per period. Two bases (8 and 20 dollars), three compounding rates (low, medium and high) and three delays (2, (...) 4, and 6 weeks) are each used. There are also 2 initial periods (Today and 2 weeks) and there are two separate questionnaires, one with lower “realistic” compounding rates and the other with higher compounding rates, typical of those used in previous studies. We analyze the detailed patterns of choice in 6 groups of 6 related questions each (in which the base and rate is fixed but the initial period and delay varies), documenting the frequency of patterns consistent with exponential discounting and with hyperbolic discounting. We find that exponential discounting is the clear modal choice pattern in virtually all cases. Hyperbolic discounting is never the modal pattern (except in the sense that constant discounting is a special case of hyperbolic discounting). We also estimate a linear probability model that takes account of individual heterogeneity. The estimates show substantial increases in the probability of choosing the later option when the compounding rate increases, as one would expect. There are small, sometimes significant, increases in this probability when the delay is increased or the initial period is in the future. Such behavior is consistent with hyperbolic discounting, but can account for only a small proportion of choices. Overall, deviations from exponential discounting appear to be due to error, or to other effects not accounted for by hyperbolic discounting. Principal among these is an increase in later choices when the base is larger. (shrink)

Corporate social responsibility (CSR) is an area of great interest, yet little is known about how CSR is perceived and practiced in the professional sport industry. This study employs a mixed-methods approach, including a survey, and a qualitative content analysis of responses to open-ended questions, to explore how professional sport executives define CSR, and what priorities teams have regarding their CSR activities. Findings from this study indicate that sport executives placed different emphases on elements of CSR including a focus on (...) philanthropic activities and ethical behaviors. The data suggest that professional sport executives view CSR as a strategic imperative for their business. Sport executives indicated that a number of factors influenced the practice of their CSR including: philanthropy (altruistic giving), an emphasis on the local community, partnerships, and ethical concerns. We also examine important organizational variables for sport (winning, revenues, and team value) and highlight their relationship with reported CSR involvement. We discuss the implications of the findings and propose recommendations for both theory and practice. (shrink)

Organisations that design and deploy artificial intelligence (AI) systems increasingly commit themselves to high-level, ethical principles. However, there still exists a gap between principles and practices in AI ethics. One major obstacle organisations face when attempting to operationalise AI Ethics is the lack of a well-defined material scope. Put differently, the question to which systems and processes AI ethics principles ought to apply remains unanswered. Of course, there exists no universally accepted definition of AI, and different systems pose different ethical (...) challenges. Nevertheless, pragmatic problem-solving demands that things should be sorted so that their grouping will promote successful actions for some specific end. In this article, we review and compare previous attempts to classify AI systems for the purpose of implementing AI governance in practice. We find that attempts to classify AI systems proposed in previous literature use one of three mental models: _the Switch_, i.e., a binary approach according to which systems either are or are not considered AI systems depending on their characteristics; _the Ladder_, i.e., a risk-based approach that classifies systems according to the ethical risks they pose; and _the Matrix_, i.e., a multi-dimensional classification of systems that take various aspects into account, such as context, input data, and decision-model. Each of these models for classifying AI systems comes with its own set of strengths and weaknesses. By conceptualising different ways of classifying AI systems into simple mental models, we hope to provide organisations that design, deploy, or regulate AI systems with the vocabulary needed to demarcate the material scope of their AI governance frameworks. (shrink)

In this essay, I consider how to conceptualize “diasporic” subjects, namely those whose identities and homes cannot be easily attributed, with regard to the political and racial dynamics of intra-group tensions, alliances, and divergences of interest. These concerns are important relatives to topics that Critical Race Theorists and Critical Race Feminists have readily addressed, such as the war on terror, the not-so-gradual erosion of dignity and rights protections accorded to non-citizens, and the increasing antagonism, surveillance, and brutality toward Latino and (...) Muslim migrants. As such, the former issues should become central concerns for Critical Race Theorists. In what follows, I want to introduce a framework called “interstitiality” as a way to address them. (shrink)

R.I.G Hughes offers the first detailed and accessible analysis of the Hilbert-space models used in quantum theory and explains why they are so successful.

This essay explores some of the elements by which Muslim women who wear the hijab in the United States are managed so as to produce and distinguish "unruly" from "good" Muslim female citizens within the context of American liberation. Unlike the French state, which has regulated both the hijab and niqab through national legislation, the American liberal framework utilizes a laissez-faire approach, which relies on a range of public and private institutions to determine acceptable public presentations of the liberal female (...) subject. I refer to this form of management as "neoliberalism." Neoliberalism management works in conjunction with popular political discourses and domestic events in ways that alternately contract and expand the boundaries that allow "suitable Muslim women" in the public sphere. (shrink)

After tracing the development of the doctrines of avatāra and incarnation, the two are compared and contrasted. Some nuanced differences are: (1) Avatāras descend repeatedly, while Christ comes only once. However, we must also reckon with the Second Coming of Christ and the possibility of many incarnations. (2) The avatāra is real but perfect because it is made of "pure matter," while the incarnation is imperfect. (3) Avatāras have different purposes and, unlike the incarnation, not every Avatāra grants salivation. The (...) two concepts are not so incompatible as may appear at first, yet the differences spring from the contrasting worldviews of the respective religions. The two beliefs can also be mutually complementary. (shrink)

The veil has remained controversial in the US since 9/11, yet it has not been subject to explicit regulation. Beginning with a court case in which a Muslim woman is banned from the courtroom for refusing a judge’s order to remove her niqab, I explore the ways in which the judge’s order resembles a demand for transparency. Transparency as a norm, a mode of discourse, and a kind of comportment betrays the explicit ethos of secular-liberal political norms and practices as (...) being purely procedural. Drawing on early immigration law, the PATRIOT Act, and other laws, I argue that transparency is a demand for “unfamiliar” strangers to present themselves as familiar, or at least, as unthreatening to the dominant, homogenous population—not merely through sincerity and collegiality, but through submission and obedience. The demand for transparency is also often an impossible demand for a gendered racial and cultural recomportment, that is, to transform oneself into someone familiar—a neutral, vaguely feminist, liberal subject. I conclude that transparency remains in excess of liberal political and civic culture’s explicit scope. (shrink)

In this article, I explore Namita Goswami’s Subjects That Matter. Goswami has laid out an extensive excavation of the variety, depth, and breadth of antagonistic encounters between the Western world and subaltern subjects. I am interested in Goswami’s take on the production of the unknowable women of color who are constructed either as good wives, animate objects without wills of their own, or transgressors of the genre of producing women of color as oppressed. I argue that the question of heterogeneity (...) already assumes the very thing that is under question: to presuppose heterogeneity is already to presuppose its limit conditions—to already understand what difference looks like, which could preempt the possibility of infinite, or indefinite iterations. The irony is that we run the risk of assuming the very thing that we are trying not to presuppose, anticipate, or cordon off. Moreover, I question whether it is possible to encounter deep radical differences in any way other than antagonistically, since the unknown, from experience, is assumed to threaten. (shrink)

Paul Taylor’s essay ‘Black Reconstruction in Aesthetics,’ explores the questions of what reconstruction in aesthetics means. He asks how reconstruction, as a program for the post-bellum Southern United States, took up certain kinds of racially inclusive agendas even as it remained myopic to fundamental, seemingly insurmountable racial, racist, sentiments. I turn to his book to illuminate some of the myopias and seemingly intractable racisms that he seems to refer to in the essay, and then return to his essay, where he (...) answers some of those questions. I argue that he is correct in his analysis. I turn to several critics’ responses of the film Moonlight, which received rave reviews, to illustrate the point that there are similar sentiments in other current seemingly progressive contexts. (shrink)

Drawing on Heidegger and Foucault, I argue that we need to understand race as a technology. Race has three technological dimensions: instrumental, naturalizing, and concealment. Through this understanding, I hope to bridge two discourses that appear disconnected: Race as Color, Blood, and Genealogy (RC), which sees race as phenotypical or biological, and eclipses a discussion of political power, and Political Othering (PO), which eclipses race in its accounts of political ostracization. Finally, the implications of thetechnology of race can be understood (...) by turning to Heidegger’s notion of Enframing, Foucault’s notion of the racist state, and Benjamin’s articulation of the inherent violence of law. (shrink)

In this first paperback edition, a new introduction by Tom Burke establishes the ongoing importance of Sleeper's analysis of the integrity of Dewey's work and ...

The January 2021 attacks on the US Capitol prompt a renewed look at the relationship between violence and Western liberal democracies. The attacks were viewed in a race-neutral frame of staging an insurrection against a procedurally elected government of a liberal democracy. Without considering the racial-political context, we are susceptible to recognizing only certain iterations of political violence while missing others altogether. In what follows, I argue that political violence against nonwhites is often not seen as violence or harm committed (...) against the polity; instead, it is frequently treated as a form of “self-defense,” enacted by white members of the polity. To illustrate my argument, I contrast the political principles and conditions under which the January 6 attacks were recognized as political violence with similar attacks in the twentieth century as they had been launched against African Americans who were attempting to participate in elections and run for office. (shrink)

Nostra Aetate urges Christians to enter into dialogue and collaboration with religions, and to acknowledge, preserve and encourage the spiritual and moral truths found in them. It is in this spirit that this article makes a comparative theological study of altruistic love in the Christian and Buddhist Scriptures. Such comparison does not only facilitate better mutual understanding but also helps each tradition to understand itself better. The New Testament favours agape and related words to express the idea of altruistic love, (...) while Buddhism uses the words metta and karuna. After presenting the main characteristics of altruistic love in Christianity and in Theravada and Mahayana Buddhism, the article launches into the theological comparison. Christian and Buddhist love are altruistic and universal. Both are opposed to malice and cruelty, are forgiving and move one to transfer one's merit, and both go to the extent of loving one's enemy and even sacrificing one's life for another. But there are many differences arising from their different worldviews. Christians love others because God has loved them, but in Theravada the motivation is different, since there is no Supreme Being. In Mahayana the Buddhas will not forgive people unless they forgive others. However, it is not the Buddhas who are the highest, but it is the Adi Buddha that is the Supreme Being. In Theravada love is developed through personal effort, i.e., through meditation; while in Christianity love is a. (shrink)

The issue of recurrent attenders to eye casualties has received little discussion in the ethics and health policy literature. As many ophthalmology departments offer a walk-in emergency service, protocols need to be in place to ensure appropriate use of this resource and also to identify potential psychiatric comorbidity in such attenders. We illustrate the problem with a recent case.A 42-year-old woman self-presented 14 times over a 4-month period to the same ophthalmic accident and emergency unit. ….

Debra Bergoffen’s Contesting the Politics of Genocidal Rape shows us beautifully what is gained by considering rape as a consequence of genocide. What gets lost here, in relation to considering cases of rape that are not the result of such, such as gang rape, “mass rape,” or other instances of rape? Is rape qua rape a human rights violation of a sort that is articulated within the context of the “right to sexual integrity”? Can a case be made, even in (...) “non-wartime” societies where rape occurs systematically as an instance of patriarchy and misogyny, that rape is a human rights violation of the right to sexual self-determination? Or is it the case that the conditions of wartime rape merit a different set of considerations in order to locate it as a human rights violation? My comments attempt to think through some of these questions with Bergoffen. (shrink)